PRF Procedure

PRF procedure is currently gaining prominence and is accepted within the medical field as an important tool that aids fast recovery by concentrating natural healing resources from your own body. From stem cells to white blood cells and platelets, we are getting thrilling and new methods that utilize this procedure promoting faster healing. Among those at the forefront of the charge with platelet-rich fibrin (PRF) is the dental world. When we use your own platelet-rich fibrin (PRF) your healing potential is enhanced.

What is PRF Procedure?

Platelet-Rich Fibrin (PRF) facilitates healing in onlay and inlay grafts, ridge augmentation procedures, bone grafting for dental implants, sinus floor elevation procedures and mending of bone defects created by removal of lesions or teeth, including the mending of fistulas between the mouth and the sinus cavity. To the surgeon who places dental implants, it is of great benefit. With the addition of PRF, bone can be grown faster and more predictably than before by an advanced implant dentist, with less complications.

PRF History

PRF (platelet-rich fibrin) was used in the area of oral maxillofacial surgery in France where it was first developed. Dr. Choukroun was the person to develop this technique for the preparation of PRF in 2000. In the current PRF method, no anticoagulant or bovine thrombin is used (like in the previous platelet-rich plasma). PRF is a platelet-rich fibrin and leukocyte biomaterial which is rich in growth factors that enhance healing.

How Dr. Berzin Uses PRF?

No different than when you go for a blood test at your family doctor, a small amount of your own blood is drawn into vials pre-procedure. These vials are then placed in a centrifuge with very specific parameters. The fibrin clot with both powerful growth factors and white blood cells is separated out to be used in the surgical site. This fibrin clot (PRF) enhances surgical results and decreases healing time. As the blood used is from the patient’s own body, disease transmission is not a factor.

Dr. Berzin will apply the PRF to the surgical area. This will accelerate healing, minimize the negative effects of the inflammatory process, enhance the clinical results, and finally decrease the amount of discomfort post-surgery.

How PRF Procedures Works?

Step 1: Blood Extraction

An important advantage of PRF is that the preparation protocol is simplified. Sterile 10ml vacutainer tubes are used to draw blood from the patient during or before the surgery. Within two minutes after collection of the blood sample, the tubes with the drawn blood are placed in the centrifuge and are processed using a single centrifugation step.

Step 2: Centrifugation

To avoid vibrations when the centrifugation process is being performed and to equilibrate the centrifugation forces, the tubes should be balanced by opposing tubes at all times. The process of centrifugation separates the blood drawn into three layers and coagulation takes place. The acellular plasma being at the top of the tube, an intensely polymerized fibrin clot in the middle, and the red blood cells at the bottom of the tube. The fibrin clot, which is rich in growth factors that enhance healing, is then ready to be removed from the tube to be used in the surgical site, after processing.

Step 3: PRF Application

The PRF clots can be processed into membranes or plugs, to be utilized in the surgical site of different procedures and applications, to enhance the healing process.

Benefits of PRF Procedure

Restoration of Peri-Implant Bone

Implants can substitute for your natural teeth after you lose them. Implants look like natural teeth that are seated in your jaw. If they are well-maintained, they could last for a lifetime. In cases where you have less bone surrounding your implants, PRF assists in the natural process of surrounding them with healthy bone. PRF assists in bone regeneration by optimizing osteoblastic differentiation and depositing osteoblasts (bone-forming cells) to the affected area using the help of stem cells.


Because PRF is a by-product of your own blood, it is quick, effective and safe. Another benefit is the elimination of disease transmission as these are your own blood cells, with no other additives. While the outpatient surgical procedure is being performed, a small quantity of your blood is taken with the use of an IV. The blood is set in a centrifuge machine to create the PRF and within 15 minutes, the PRF is made and ready for use.


PRF is rapidly produced in our office while you are going through an outpatient oral procedure, such as placing dental implants and other surgical procedures. The PRF procedure results in supersaturation of the wound with growth factors, increased vascularization, with faster healing and tissue regeneration.

Increased Clinical Performance

It has been proven in the latest research, that as compared to previous generation PRP, the new harvesting process for PRF, shows a better expression as well as higher concentration of growth factors and protein matrix, that are released over a prolonged period of time, because of the three-dimensional structure of the adhesive glycoproteins available in the fibrin clot. PRF exhibits an increased release of growth factors for about 10 days, which promotes significantly higher growth factor release in the long run, and in turn delivers significantly improved regenerative and healing capacity.

No Contraindications

There are no contraindications to the usage of PRF. It can be used for any kind of patient, specifically in surgically compromised situations or patients that have systemic conditions that manifest in compromised healing (e.g. smokers and diabetics). PRF will aid healing and minimize the risk of complications after surgery. Fibrin-based platelet concentrates are often used to enhance angiogenesis and lower the risk of flap necrosis in general surgery applications.


PRF has a significant capacity to regenerate tissue. It can transform stem cells into regenerative cells for gingival and bone tissue formation. PRF also enhances vascularization necessary for the regenerative process.

Relieves Periodontal Defects

On occasion where there is bone resorption (destruction) around teeth, PRF may assist in the production of new bone, and as a result, improve the health of your teeth. PRF can help reduce the pocket probing depth around teeth as well.

Final Words

Like any other healthcare field, dentistry has gained from the current development in regenerative medicine. PRF is a third-generation platelet concentrate, an upgrade of the standard PRP. With the assistance of Dr. Berzin, who has extensive experience over more than 20 years, you will be able to show off your perfect smile. Give your family and friends your biggest beam and share your happiness with them. Call to find out more by contacting Dr. Berzin Dental Implants number (647) 352-5577 and schedule your next appointment with us today.

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